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When a character defends equipped with the Crossguard 2X, how much is pierce reduced by? For example's sake, let's say the character has 3 base defense.

Crossguard looks at the defender's total defense after the attacker flips (i.e. before the defender flips battle cards). So a base defense of 3, plus the +2 from Crossguard, means that it reduces Pierce by 5, assuming no other effects.
Source: Aequitas (2022-09-15)    【Link to Ruling】
Tags: Decepticon Doublecrosser, Shield Brothers